Health Effects drive legislation and the control strategies of toxic metals. Projects study the exposure risks of metals on target tissues of the nervous, endocrine, and cardiopulmonary systems at the molecular, cellular, and tissue levels in animal and human subjects. CATM is developing, demonstrating, and applying innovative approaches to characterize risk and evaluate preventive and protective measures. A comprehensive approach is used to define and correlate relationships that will prove useful to legislators and those developing control strategies. Current efforts focus on:
- Identifying mercury-selenium interactions and possible ways to partially offset the toxicity of trace metals.
- Evaluating the role of selenium in aquatic environments and implications for mercury bioaccumulation.
- Assessing mercury's impacts on growth and development through animal studies.
- Examining heavy metal accumulation in the development and pathology of cardiac disease.
Program Area 4 Projects
| • | Molecular Interactions of Toxic Metals (2006, 593 KB PDF) |
| • | Mercury–Selenium Interactions in Aquatic Ecosystems (2006, 755 KB PDF) |
| • | Mercury Metabolism and Selenium Physiology Studies (2006, 771 KB PDF) |
| • | Mercury's Interaction with Selenium (2006, 241 KB PDF) |
| • | Physiologically Based Pharmacokinetic Model of Mercury-Selenium Interactions (2006, 964 KB PDF) |
| • | Mercury and Air Toxic Element Impacts of Coal Combustion By-Product Disposal and Utilization (2005, 48 KB PDF) |
| • | Molecular Interactions of Toxic Metals (2005, 97 KB PDF) |
| • | Mercury–Selenium Interactions in Aquatic Ecosystems (2005, 345 KB PDF) |
| • | Mercury Metabolism and Selenium Physiology Studies (2005, 524 KB PDF) |
| • | Mercury Metabolism and Selenium Physiology Studies (2004, 413 KB PDF) |
| • | Studies of Mercury Metabolism and Selenium Physiology (2003, 117 KB PDF) |
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